论文标题
DS-GCNS:使用助理任务培训的动态光谱图卷积网络进行连接分类
DS-GCNs: Connectome Classification Using Dynamic Spectral Graph Convolution Networks with Assistant Task Training
论文作者
论文摘要
功能连通性(FC)矩阵测量大脑中的区域相互作用,并已广泛用于神经系统脑疾病分类。但是,FC矩阵既不是包含形状和纹理信息的自然图像,也不是独立特征的向量,它使从矩阵中提取有效特征是一个具有挑战性的问题。大脑网络(也称为Connectome)可以自然地形成图形结构,其节点是大脑区域,边缘是区域间连通性。因此,在这项研究中,我们提出了新型的图形卷积网络(GCN),以从FC矩阵中提取有效的疾病相关特征。考虑到大脑活动的时间相关性质,我们使用滑动窗口计算了动态FC矩阵,并实现了基于图形卷积的LSTM(长度短期存储器)层以过程动态图。此外,患者的人口统计学也被用来指导分类。但是,与传统方法不同的方法(即添加性别和年龄作为额外意见)的传统方法不同,我们认为这种方法实际上可能不会改善分类性能,因为数据集中给出的此类个人信息通常是平衡的。在本文中,我们建议将人口统计信息用作额外的输出,并在预测主题状态,性别和年龄的三个网络中共享参数,这些网络是助理任务。我们测试了ADNI II数据集中提出的结构的性能,以对正常对照组对阿尔茨海默氏病患者进行分类。在ADNI II数据集上,分类精度,灵敏度和特异性达到0.90、0.92和0.89。
Functional Connectivity (FC) matrices measure the regional interactions in the brain and have been widely used in neurological brain disease classification. However, a FC matrix is neither a natural image which contains shape and texture information, nor a vector of independent features, which renders the extracting of efficient features from matrices as a challenging problem. A brain network, also named as connectome, could forma a graph structure naturally, the nodes of which are brain regions and the edges are interregional connectivity. Thus, in this study, we proposed novel graph convolutional networks (GCNs) to extract efficient disease-related features from FC matrices. Considering the time-dependent nature of brain activity, we computed dynamic FC matrices with sliding-windows and implemented a graph convolution based LSTM (long short term memory) layer to process dynamic graphs. Moreover, the demographics of patients were also used to guide the classification. However, unlike in conventional methods where personal information, i.e., gender and age were added as extra inputs, we argue that this kind of approach may not actually improve the classification performance, for such personal information given in dataset was usually balanced distributed. In this paper, we proposed to utilize the demographic information as extra outputs and to share parameters among three networks predicting subject status, gender and age, which serve as assistant tasks. We tested the performance of the proposed architecture in ADNI II dataset to classify Alzheimer's disease patients from normal controls. The classification accuracy, sensitivity and specificity reach 0.90, 0.92 and 0.89 on ADNI II dataset.