论文标题
自由形式的微流体网络封装在激光印刷的三维宏观玻璃对象中
Freeform microfluidic networks encapsulated in laser printed three-dimensional macro-scale glass objects
论文作者
论文摘要
基础研究和工业应用都高度需求，具有复杂的三维（3D）配置的大型微流体微型系统，具有促进广泛的创新应用的潜力，例如实验室芯片和有机体芯片和诸如An-a-a-a-a-chip以及连续的精美化学物质。但是，就制造分辨率，灵活性和可实现的占地面积而言，对于当前大多数制造技术而言，自由形式的制造仍然具有挑战性。在这里，我们报告了具有高纵横比和嵌入3D印刷玻璃对象的可调直径的自由形小流体电路的Ultrashort脉冲激光器微加工。我们通过小心地沿微流体通道仔细分配一串额外的访问端口来实现均匀的微流体通道直径，以避免在薄薄的微流体通道中过度蚀刻。化学蚀刻完成后，使用二氧化碳激光诱导的局部玻璃熔化将额外的访问端口密封。我们演示了融合二氧化硅的模型手，尺寸约为3 cm * 2.7 cm * 1.1 cm，其中整个血管系统被封装。
Large-scale microfluidic microsystems with complex three-dimensional (3D) configurations are highly in demand by both fundamental research and industrial application, holding the potentials for fostering a wide range of innovative applications such as lab-on-a-chip and organ-on-a-chip as well as continuous-flow manufacturing of fine chemicals. However, freeform fabrication of such systems remains challenging for most of the current fabrication techniques in terms of fabrication resolution, flexibility, and achievable footprint size. Here, we report ultrashort pulse laser microfabrication of freeform microfluidic circuits with high aspect ratios and tunable diameters embedded in 3D printed glass objects. We achieve uniform microfluidic channel diameter by carefully distributing a string of extra access ports along the microfluidic channels for avoiding the over-etching in the thin microfluidic channels. After the chemical etching is completed, the extra access ports are sealed using carbon dioxide laser induced localized glass melting. We demonstrate a model hand of fused silica with a size of ~3 cm * 2.7 cm * 1.1 cm in which the whole blood vessel system is encapsulated.
