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In-band full-duplex systems can transmit and receive information simultaneously on the same frequency band. However, due to the strong self-interference caused by the transmitter to its own receiver, the use of non-linear digital self-interference cancellation is essential. In this work, we describe a hardware architecture for a neural network-based non-linear self-interference (SI) canceller and we compare it with our own hardware implementation of a conventional polynomial based SI canceller. In particular, we present implementation results for a shallow and a deep neural network SI canceller as well as for a polynomial SI canceller. Our results show that the deep neural network canceller achieves a hardware efficiency of up to $312.8$ Msamples/s/mm$^2$ and an energy efficiency of up to $0.9$ nJ/sample, which is $2.1\times$ and $2\times$ better than the polynomial SI canceller, respectively. These results show that NN-based methods applied to communications are not only useful from a performance perspective, but can also be a very effective means to reduce the implementation complexity.