论文标题
从多种乳液中建模药物输送
Modelling drug delivery from multiple emulsions
论文作者
论文摘要
我们提出了一种从多重乳液到外部流体的药物释放的机械模型。我们考虑了一个多层液滴，其中通过不同的液体壳通过纯扩散过程来描述药物动力学。多层问题由通过层间条件结合的扩散方程系统描述，从而施加了药物浓度和通量的连续性。通过在液滴的外表面上施加表面活性剂，在外界施加了质量电阻。二维问题通过有限的体积离散化来解决。提出了三个典型的圆形（圆形，椭圆和子弹）液滴的浓度曲线和药物释放曲线，以及在分析表面时溶液对传质系数的依赖性。主要结果表明释放时间减少了液滴伸长的时间。
We present a mechanistic model of drug release from a multiple emulsion into an external surrounding fluid. We consider a single multi-layer droplet where the drug kinetics are described by a pure diffusive process through different liquid shells. The multi-layer problem is described by a system of diffusion equations coupled via interlayer conditions imposing continuity of drug concentration and flux. Mass resistance is imposed at the outer boundary through the application of a surfactant at the external surface of the droplet. The two-dimensional problem is solved numerically by finite volume discretization. Concentration profiles and drug release curves are presented for three typical round-shaped (circle, ellipse and bullet) droplets and the dependency of the solution on the mass transfer coefficient at the surface analyzed. The main result shows a reduced release time for an increased elongation of the droplets.
