论文标题
对COVID-19诊断，疫苗和医学的解码SARS-COV-2传播，进化和后果
Decoding SARS-CoV-2 transmission, evolution and ramification on COVID-19 diagnosis, vaccine, and medicine
论文作者
论文摘要
由于严重的急性急性呼吸综合症冠状病毒2（SARS-COV-2），针对冠状病毒病（CoVID-19）的诊断测试，预防性疫苗和治疗性药物的开发已付出了巨大的努力。这种发展的大部分是基于2020年1月5日收集的参考基因组。基于截至2020年4月24日收集的6156个基因组样本的基因分型，我们报告说，SARS-COV-2具有4459个令人震惊的突变，可以将其聚集在五个亚型中。我们介绍了突变比和突变$ H $索引，以表征蛋白质保守性和揭露，即SARS-COV-2包膜蛋白，主要蛋白酶和内核酸酶蛋白质蛋白是相对保守的，而SARS-COV-2核蛋白质，Spike蛋白，Spike蛋白和Papain-like蛋白酶相对不易于维护。特别是，在过去的几个月中，Nucleocapsid蛋白具有一半以上的基因变化，这对Covid-19诊断，疫苗和药物的持续发展产生了毁灭性影响。
Tremendous effort has been given to the development of diagnostic tests, preventive vaccines, and therapeutic medicines for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much of this development has been based on the reference genome collected on January 5, 2020. Based on the genotyping of 6156 genome samples collected up to April 24, 2020, we report that SARS-CoV-2 has had 4459 alarmingly mutations which can be clustered into five subtypes. We introduce mutation ratio and mutation $h$-index to characterize the protein conservativeness and unveil that SARS-CoV-2 envelope protein, main protease, and endoribonuclease protein are relatively conservative, while SARS-CoV-2 nucleocapsid protein, spike protein, and papain-like protease are relatively non-conservative. In particular, the nucleocapsid protein has more than half its genes changed in the past few months, signaling devastating impacts on the ongoing development of COVID-19 diagnosis, vaccines, and drugs.
