论文标题
根据Anfinsen Dogma的变质蛋白
Metamorphic Proteins in light of the Anfinsen Dogma
论文作者
论文摘要
普遍认为，变质蛋白会挑战Anfinsen热力学假设（或Dogma）。在这里，我们反对这种观点的目的是表明变质蛋白不仅满足Anfinsen教条，而且表现出与大分子和大分子复合物上所见的边际稳定性。这项工作有助于我们对蛋白质分类的一般理解，并可能刺激我们分析蛋白质可发展性的努力。
It is a common belief that metamorphic proteins challenge the Anfinsen thermodynamic hypothesis (or dogma). Here we argue against this view aims to show that metamorphic proteins not just fulfill the Anfinsen dogma but also exhibit marginal stability comparable to that seen on macromolecules and macromolecular complexes. This work contributes to our general understanding of protein classification and may spur significant progress in our effort to analyze protein evolvability.
