论文标题
在生长上皮组织中的干扰和力分布
Jamming and force distribution in growing epithelial tissue
论文作者
论文摘要
我们使用新开发的用于机械细胞分裂和2D迁移的数值模拟模型来研究增殖细胞组织的形态。该模型应用于由具有低生长潜力和具有高生长电位的软细胞组成的双峰混合物。通常认为癌细胞比健康细胞柔软。在均匀的混合物中，软细胞发展成组织基质，将僵硬的细胞发展成树突状的网络结构。当将软细胞放置在由僵硬细胞组成的组织中（以模拟癌症生长）时，软细胞会发展为快速生长的肿瘤样结构，逐渐撤离僵硬的细胞基质。该模型还证明了1）软细胞如何朝着Bischofs和Schwarz（Proc。Natl。Acad。Sci。Sci。Sci.U.Sci.A.，100，9274---9279（2003）（2003）和2）所预测的最大有效刚度方向定向，并产生了几个细胞row的界面。随着细胞间摩擦的增加，肿瘤生长会减慢并发生细胞死亡。证明细胞之间的接触力分布对细胞类型的混合物和细胞 - 细胞相互作用高度敏感，这表明局部机械力可以作为组织形成的调节剂。结果为既定的实验数据提供了新的启示。
We investigate morphologies of proliferating cellular tissues using a newly developed numerical simulation model for mechanical cell division and migration in 2D. The model is applied to a bimodal mixture consisting of stiff cells with a low growth potential and soft cells with a high growth potential; cancer cells are typically considered to be softer than healthy cells. In an even mixture, the soft cells develop into a tissue matrix and the stiff cells into a dendrite-like network structure. When soft cells are placed inside a tissue consisting of stiff cells (to model cancer growth), the soft cells develop to a fast growing tumor-like structure that gradually evacuates the stiff cell matrix. The model also demonstrates 1) how soft cells orient themselves in the direction of the largest effective stiffness as predicted by the theory of Bischofs and Schwarz (Proc. Natl. Acad. Sci U.S.A., 100, 9274--9279 (2003) and 2) that the orientation and force generation continue a few cell rows behind the soft-stiff interface. With increasing inter-cell friction, tumor growth slows down and cell death occurs. The contact force distribution between cells is demonstrated to be highly sensitive to cell type mixtures and cell-cell interactions, which indicates that local mechanical forces can be useful as a regulator of tissue formation. The results shed new light on established experimental data.
