论文标题
在视觉工作记忆任务中，癫痫儿童中的脑电图来源定位分析
EEG source localization analysis in epileptic children during a visual working-memory task
论文作者
论文摘要
我们基于在视觉歧视工作记忆任务中获得的脑电图记录，将癫痫儿童的大脑活动来源定位。对于逆问题的数值解决方案，借助于公开可用的数据库处理的特定年龄MRI扫描，我们使用并比较了三种正则化数值方法，即标准的低分辨率电磁层造影（SLORETA）（SLORETA），即加权最小规范估计（WMNE），即动态统计统计参数（Dynical Partimentions ParameTric paragepm）。我们表明，所有三种方法都提供了癫痫和对照儿童之间相同的时空差异模式。特别是，我们的分析揭示了顶叶区域中两组之间在统计上显着的差异，表明这些差异可能是诊断目的的“生物标志物”，并最终是局部局部治疗。
We localize the sources of brain activity of children with epilepsy based on EEG recordings acquired during a visual discrimination working memory task. For the numerical solution of the inverse problem, with the aid of age-specific MRI scans processed from a publicly available database, we use and compare three regularization numerical methods, namely the standarized Low Resolution Electromagnetic Tomography (sLORETA), the weighted Minimum Norm Estimation (wMNE) and the dynamic Statistical Parametric Mapping (dSPM). We show that all three methods provide the same spatio-temporal patterns of differences between epileptic and control children. In particular, our analysis reveals statistically significant differences between the two groups in regions of the Parietal Cortex indicating that these may serve as "biomarkers" for diagnostic purposes and ultimately localized treatment.
