论文标题
从概念到临床试验：iVist-第一个基于多传感器的实时体内剂量测定平台和HDR近距离放射治疗中的来源跟踪
From conception to clinical trial: IViST -- the first multi-sensor-based platform for real-time In Vivo dosimetry and Source Tracking in HDR brachytherapy
论文作者
论文摘要
这项研究旨在引入IVIST（体内源跟踪），这是一个新型的多传感器剂量测定平台，用于HDR近距离放射治疗中实时治疗监测。 Ivist是一个包括3个部分的平台：1）优化且具有特征的多点塑料闪光灯仪（3分MPSD；使用BCF-60； BCF-60，BCF-12和BCF-10闪烁体），2）2）紧凑型光电管（PMTS）的紧凑型和3个含量均匀镜像，并刻画了3个高高的镜像，并将用于系统管理和信号处理的基于Python的图形用户界面。静脉曲张可以同时测量剂量，三角测量源位置并测量停留时间。通过进行100,000个测量值/s，静脉输液样本足够的数据可以快速执行关键的QA/QC任务，例如识别错误的单个停留时间或互换转移管。通过将3个共线性传感器和计划的信息用于植入物几何形状（来自DICOM RT），该平台还可以实时进行三角测量源位置。目前，使用静脉系统正在进行临床试验。
This study aims to introduce IViST (In Vivo Source Tracking), a novel multi-sensors dosimetry platform for real-time treatment monitoring in HDR brachytherapy. IViST is a platform that comprises 3 parts: 1) an optimized and characterized multi-point plastic scintillator dosimeter (3 points mPSD; using BCF-60, BCF-12, and BCF-10 scintillators), 2) a compact assembly of photomultiplier tubes (PMTs) coupled to dichroic mirrors and filters for high-sensitivity scintillation light collection, and 3) a Python-based graphical user interface used for system management and signal processing. IViST can simultaneously measure dose, triangulate source position, and measure dwell time. By making 100 000 measurements/s, IViST samples enough data to quickly perform key QA/QC tasks such as identifying wrong individual dwell time or interchanged transfer tubes. By using 3 co-linear sensors and planned information for an implant geometry (from DICOM RT), the platform can also triangulate source position in real-time. A clinical trial is presently on-going using the IViST system.
