论文标题
使用高强度γ射线源的医学有趣的异构体的照片兴趣产生
Photo-excitation production of medically interesting isomers using high-intensity γ-ray source
论文作者
论文摘要
光子诱导的核激发（即照片兴奋）可用于生产核异构体，这些核异构体在天体物理学，能量存储以及医学诊断和治疗中可能应用。本文介绍了一项可行性研究，该研究使用基于激光 - 电子康普顿散射（LCS）的高强度γ射线源（LCS），用于医学诊断和治疗。审查了这些核异构体的衰减特性和医疗应用。计算了每个光兴趣过程的横截面曲线，模拟的产量和活性。通过调整电子能量以最大化产量以及光兴激素产品的活性，通过调节电子能量来优化LCSγ射线束的截止能。发现上述异构体的可实现活性可以超过10 mci，对于6小时目标照射，其强度为10^{13}γ/s。这种活动的幅度满足了医学诊断的剂量需求。我们的仿真结果表明，使用最先进的LCSγ射线束设备产生具有光启示的医学有趣的异构体的前景。
Photon-induced nuclear excitation (i.e. photo-excitation) can be used for production of nuclear isomers, which have potential applications in astrophysics, energy storing, and medical diagnosis and treatment. This paper presents a feasibility study on production of four nuclear isomers ({99m}^Tc, {103m}^Rh and {113m, 115m}^In) using high-intensity γ-ray source based on laser-electron Compton scattering (LCS), for use in the medical diagnosis and treatment. The decay properties and the medical applications of these nuclear isomers were reviewed. The cross-section curves, simulated yields and activity of product of each photo-excitation process were calculated. The cutoff energy of LCS γ-ray beam is optimized by adjusting the electron energy in order to maximize the yields as well as the activities of photo-excitation products. It is found that the achievable activity of above-mentioned isomers can exceed 10 mCi for 6-hour target irradiation at an intensity of the order of 10^{13} γ/s. Such magnitude of activity satisfies the dose requirement of medical diagnosis. Our simulation results suggest the prospect of producing medically interesting isomers with photo-excitation using the state-of-art LCS γ-ray beam facility.
