论文标题
基于自由相似性的血管造影(SIMBA),用于简化心脏的解剖学MR成像
Free-running SIMilarity-Based Angiography (SIMBA) for simplified anatomical MR imaging of the heart
论文作者
论文摘要
目的:全心MRA技术通常以预定的运动状态为目标,并独立解决心脏和呼吸动力学。我们提出了一种新颖的快速重建算法,适用于未经序列的自由运行序列,该算法利用了获得的数据中固有的相似性来避免这种生理约束。 理论与方法:提出的基于相似性的血管造影(SIMBA)方法将连续获得的K空间数据簇,以便找到一个可以将运动抑制的子集重建为运动抑制的全心体MRA。从六个小儿心脏病患者和十二种健康志愿者扫描的非对抗性扫描的自由运行的3D径向数据集被我们提出的SIMBA方法和以前的自由式的框架(frffrf)及其前的自由界(frffrf),对所有获取的数据(所有数据)进行了非动力抑制的重新制定(所有数据),并通过非动力抑制的重新构建。比较图像的血肌界面清晰度,对比比和冠状动脉冠状动脉的可见性。 结果:快速SIMBA重建(〜20s)和FRF都比所有数据都具有明显更高的血细胞心敏锐度(p <0.001)。前两个之间没有观察到显着差异。与所有数据相比,SIMBA获得的血宫心肌对比比明显更高(p <0.01)。与所有数据相比,与Simba和FRF相比,可以同时可以看到更多的冠状动脉OSTIA(所有数据:4/36,SIMBA:30/36,FRF:33/36,均P <0.001),但在前两个之间没有发现显着差异。 结论:自由运行序列和快速的Simba重建的组合(无与生理运动相关的先验假设,都形成了一个简单的工作流程,用于获得具有尖锐解剖结构的全心MRA。
Purpose: Whole-heart MRA techniques typically target pre-determined motion states and address cardiac and respiratory dynamics independently. We propose a novel fast reconstruction algorithm, applicable to ungated free-running sequences, that leverages inherent similarities in the acquired data to avoid such physiological constraints. Theory and Methods: The proposed SIMilarity-Based Angiography (SIMBA) method clusters the continuously acquired k-space data in order to find a motion-consistent subset that can be reconstructed into a motion-suppressed whole-heart MRA. Free-running 3D radial datasets from six ferumoxytol-enhanced scans of pediatric cardiac patients and twelve non-contrast scans of healthy volunteers were reconstructed with a non-motion-suppressed regridding of all the acquired data (All Data), our proposed SIMBA method, and a previously published free-running framework (FRF) that uses cardiac and respiratory self-gating and compressed sensing. Images were compared for blood-myocardium interface sharpness, contrast ratio, and visibility of coronary artery ostia. Results: Both the fast SIMBA reconstruction (~20s) and the FRF provided significantly higher blood-myocardium sharpness than All Data (P<0.001). No significant difference was observed among the former two. Significantly higher blood-myocardium contrast ratio was obtained with SIMBA compared to All Data and FRF (P<0.01). More coronary ostia could be visualized with both SIMBA and FRF than with All Data (All Data: 4/36, SIMBA: 30/36, FRF: 33/36, both P<0.001) but no significant difference was found between the first two. Conclusion: The combination of free-running sequences and the fast SIMBA reconstruction, which operates without a priori assumptions related to physiological motion, forms a simple workflow for obtaining whole-heart MRA with sharp anatomical structures.