论文标题

墨西哥城市糖尿病研究中基于副群体的完全贝叶斯非参数评估

A Copula-based Fully Bayesian Nonparametric Evaluation of Cardiovascular Risk Markers in the Mexico City Diabetes Study

论文作者

Wehrhahn, Claudia, Fuentes-García, Ruth, Mena, Ramsés H., Leisen, Fabrizio, González-Villalpando, Maria Elena, González-Villalpando, Clicerio

论文摘要

心血管疾病导致了全世界死亡的原因,并且已经进行了几项研究,以理解和探索正常血糖和糖尿病种群中的心血管风险标志物。在这项工作中,我们探讨了墨西哥城糖尿病研究中正常血糖人群的高血糖标记和由甘油三酸酯,体重指数,年龄和性别控制的心血管风险标记之间的关联结构。了解关联结构可能有助于评估这个低收入城市人口中的额外心血管风险标志物,其经典心血管风险生物标志物的流行率很高。结合结构是通过条件肯德尔的tau测量的,该tau通过条件副函数定义。后者又在完全贝叶斯非参数方法下建模,该方法使Copula函数的完整形状对于受控协变量的不同值而变化。

Cardiovascular disease lead the cause of death world wide and several studies have been carried out to understand and explore cardiovascular risk markers in normoglycemic and diabetic populations. In this work, we explore the association structure between hyperglycemic markers and cardiovascular risk markers controlled by triglycerides, body mass index, age and gender, for the normoglycemic population in The Mexico City Diabetes Study. Understanding the association structure could contribute to the assessment of additional cardiovascular risk markers in this low income urban population with a high prevalence of classic cardiovascular risk biomarkers. The association structure is measured by conditional Kendall's tau, defined through conditional copula functions. The latter are in turn modeled under a fully Bayesian nonparametric approach, which allows the complete shape of the copula function to vary for different values of the controlled covariates.

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