论文标题
重新访问使用人类从头突变数据的中性动力学限制鸟嘌呤 - 花生素含量
Revisiting the Neutral Dynamics Derived Limiting Guanine-Cytosine Content Using the Human De Novo Point Mutation Data
论文作者
论文摘要
我们在中性进化下重新审视人类基因组鸟嘌呤 - 环胞苷含量的主题。对于这项研究，人类内的从头突变数据用于估计突变率，而不是使用相关物种之间的基本替代数据。然后，我们定义了一种新的突变偏差量度，该方法将从头突变分开的计数与背景鸟嘌呤 - 环蛋白含量本身本身，从而使不同数据集之间的比较变得更加容易。我们得出了一种新的公式，用于通过将CPG涉及的突变事件分开为独立变量来计算限制鸟嘌呤 - 环蛋白含量。当考虑使用CPG涉及的突变时，使用该公式，在中性动力学的极限下，鸟嘌呤 - 环蛋白含量的下降较少。在某些假设下，我们提供了证据，表明类似等位置的结构可能仍然是中性突变动力学的限制构型。
We revisit the topic of human genome guanine-cytosine content under neutral evolution. For this study, the de novo mutation data within human is used to estimate mutational rate instead of using base substitution data between related species. We then define a new measure of mutation bias which separate the de novo mutation counts from the background guanine-cytosine content itself, making comparison between different datasets easier. We derive a new formula for calculating limiting guanine-cytosine content by separating CpG-involved mutational events as an independent variable. Using the formula when CpG-involved mutations are considered, the guanine-cytosine content drops less severely in the limit of neutral dynamics. We provide evidence, under certain assumptions, that an isochore-like structure might remain as a limiting configuration of the neutral mutational dynamics.
