论文标题
关于遗传编码起源和演变的多-TRNA模型的一些预测
On some predictions of the poly-tRNA model for the origin and evolution of genetic coding
论文作者
论文摘要
最近提出了多个基因模型的基因编码的起源和演变。该模型导致了对蛋白质合成开始时可能发生的事情的相当精确的描述。在这里，我们进一步讨论了该模型的一些有趣含义。首先，编码的肽/蛋白质合成的系统似乎是在富含RNA世界的繁殖地开始和开发的，这是造成生命生命和复杂性的起步阶段。此外，一旦蛋白质合成得到充分确定并显然取代了RNA世界，并且在生命的早期阶段开始，我们已经看到了对物种现代比较分子研究的解释，这是一个反复出现的主题：这种新生的生命实体的全部能力通过修补而发展，利用各种可用的部分来改善自己。最后，并且非常具有启发性的是，从该模型中推断出，首先生产的肽可能具有独特的特性，而不是由迄今为止的分子库共享的，这允许当时无所不能的RNA世界与脂质膜囊泡之间的功能连接。这些特定功能最初可能是达尔文式选择成熟蛋白质合成机械的起源。
The poly-tRNA model was recently presented for the origin and evolution of genetic coding. This model has led to a rather precise description of what might have occurred at the beginning of protein synthesis in the first life form. Here, we further discuss some interesting implications of this model. First, the system of encoded peptide/protein synthesis appears to have started and developed on the breeding ground of a rich RNA world, responsible for the infancy of life existence and complexity. Furthermore, once protein synthesis was fully established and apparently superseding the RNA world, and at a very early stage of life beginnings, we already see what has been a recurrent theme in the likely interpretation of modern comparative molecular studies on species: the full ability of this nascent life entity to develop itself by tinkering, using all kinds of available pieces to improve itself. Lastly, and very instructively, it is deduced from this model that the first peptides to be produced probably had unique properties, not shared by the arsenal of molecules present hitherto, which allowed a functional connection between the then omnipotent RNA world and the lipid membrane vesicles containing it. These specific functions might have initially been at the origin of the Darwinian selection of the full-blown protein-synthesis machinery.
