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Aims. Radio observing efficiency can be improved by calibrating and reducing the observations in total power mode rather than in frequency, beam, or position-switching modes. Methods. We selected a sample of spectra obtained from the Institut de Radio-Astronomie Millimétrique (IRAM) 30-m telescope and the Green Bank Telescope (GBT) to test the feasibility of the method. Given that modern front-end amplifiers for the GBT and direct Local Oscillator injection for the 30 m telescope provide smooth pass bands that are a few tens of megahertz in width, the spectra from standard observations can be cleaned (baseline removal) separately and then co-added directly when the lines are narrow enough (a few km/s), instead of performing the traditional ON minus OFF data reduction. This technique works for frequency-switched observations as well as for position- and beam-switched observations when the ON and OFF data are saved separately. Results. The method works best when the lines are narrow enough and not too numerous so that a secure baseline removal can be achieved. A signal-to-noise ratio improvement of a factor of sqrt(2) is found in most cases, consistent with theoretical expectations. Conclusions. By keeping the traditional observing mode, the fallback solution of the standard reduction technique is still available in cases of suboptimal baseline behavior, sky instability, or wide lines, and to confirm the line intensities. These techniques of total-power-mode reduction can be applied to any radio telescope with stable baselines as long as they record and deliver the ONs and OFFs separately, as is the case for the GBT.