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Object pose estimation enables robots to understand and interact with their environments. Training with synthetic data is necessary in order to adapt to novel situations. Unfortunately, pose estimation under domain shift, i.e., training on synthetic data and testing in the real world, is challenging. Deep learning-based approaches currently perform best when using encoder-decoder networks but typically do not generalize to new scenarios with different scene characteristics. We argue that patch-based approaches, instead of encoder-decoder networks, are more suited for synthetic-to-real transfer because local to global object information is better represented. To that end, we present a novel approach based on a specialized feature pyramid network to compute multi-scale features for creating pose hypotheses on different feature map resolutions in parallel. Our single-shot pose estimation approach is evaluated on multiple standard datasets and outperforms the state of the art by up to 35%. We also perform grasping experiments in the real world to demonstrate the advantage of using synthetic data to generalize to novel environments.