论文标题

杂交的基因组后果

The genomic consequences of hybridization

论文作者

Moran, Benjamin M, Payne, Cheyenne, Langdon, Quinn, Powell, Daniel L, Brandvain, Yaniv, Schumer, Molly

论文摘要

在过去的十年中,基因组测序的进步使研究人员能够发现包括我们自己在内的各种物种群体中杂交的历史。尽管该领域在记录自然杂交的程度(包括历史和近期)方面取得了令人印象深刻的进步,但关于其遗传和进化后果仍然存在许多未解决的问题。最近的工作表明,基因组中杂交的结果可能部分是可以预见的,但是许多关于杂种选择的性质以及塑造这种选择的生物学变量的许多开放性问题阻碍了该领域的进步。我们讨论了有关杂交后基因组中祖先变化的机制的了解,突出了主要的未解决问题,并讨论了它们对杂交后基因组演化的可预测性的影响。

In the past decade, advances in genome sequencing have allowed researchers to uncover the history of hybridization in diverse groups of species, including our own. Although the field has made impressive progress in documenting the extent of natural hybridization, both historical and recent, there are still many unanswered questions about its genetic and evolutionary consequences. Recent work has suggested that the outcomes of hybridization in the genome may be in part predictable, but many open questions about the nature of selection on hybrids and the biological variables that shape such selection have hampered progress in this area. We discuss what is known about the mechanisms that drive changes in ancestry in the genome after hybridization, highlight major unresolved questions, and discuss their implications for the predictability of genome evolution after hybridization.

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