论文标题

基于Lifex的开放工具,用于心脏计算模型中的肌纤维生成

An open tool based on lifex for myofibers generation in cardiac computational models

论文作者

Africa, Pasquale C., Piersanti, Roberto, Fedele, Marco, Dede', Luca, Quarteroni, Alfio

论文摘要

对整个心脏功能进行建模涉及几种复杂的多物理和多尺度模型的解决方案,这些模型在高度计算上要求,这些模型要求更简单而准确,高性能的计算工具。尽管有几个研究小组做出了努力,但在科学界,尚无用于全心全意完全耦合的心脏模拟的软件。在这项工作中,我们介绍了第一个公开发布的Lifex包,这是一个高性能的有限元求解器,用于在IHEART Project框架中开发的多物理和多规模问题。 Lifex的目标是双重的。一方面,它的目的是在硅胶实验中易于重现,可为广泛的用户社区(包括具有医学或生物工程背景的用户社区)访问。另一方面,科学计算专家可以利用学术研究库,以探索强大的开发框架内的新数学模型和数值方法。 Lifex已通过模块化结构开发,并将释放在不同的模块中。此处介绍的工具提出了一种基于Laplace-Dirichlet规则的方法的心肌纤维的创新生成器,这是对电生理,机械和机电功能进行建模的必不可少的构建块,从单室到全室模拟。该报告带有广泛的技术和数学文档,欢迎新用户进入原型Lifex应用程序的核心结构,并为它们提供可能将生成的心脏纤维包含到更复杂的计算管道中的方法。

Modeling the whole cardiac function involves the solution of several complex multi-physics and multi-scale models that are highly computationally demanding, which call for simpler yet accurate, high-performance computational tools. Despite the efforts made by several research groups, no software for whole-heart fully-coupled cardiac simulations in the scientific community has reached full maturity yet. In this work we present the first publicly released package of lifex, a high-performance Finite Element solver for multi-physics and multi-scale problems developed in the framework of the iHEART project. The goal of lifex is twofold. On the one side, it aims at making in silico experiments easily reproducible and accessible to a wide community of users, including those with a background in medicine or bio-engineering. On the other hand, as an academic research library lifex can be exploited by scientific computing experts to explore new mathematical models and numerical methods within a robust development framework. lifex has been developed with a modular structure and will be released bundled in different modules. The tool presented here proposes an innovative generator for myocardial fibers based on Laplace-Dirichlet Rule-Based Methods, which are the essential building blocks for modeling the electrophysiological, mechanical and electromechanical cardiac function, from single-chamber to whole-heart simulations. This report comes with an extensive technical and mathematical documentation to welcome new users to the core structure of a prototypical lifex application and to provide them with a possible approach to include the generated cardiac fibers into more sophisticated computational pipelines.

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