论文标题
电荷调节的脂质双层中的曲率效应
Curvature effects in charge-regulated lipid bilayers
论文作者
论文摘要
我们在脂质双层膜中制定了静电相互作用的理论，其中两个单层小叶都包含可取代的部分，这些部分可能是电荷调节的。我们特别研究了使用线性Debye-Hückel（DH）和非线性泊松泊孔玻璃体（PB）理论，膜曲率和脂质双层囊泡的膜曲率调节之间的耦合。我们发现，原本对称双层膜的电荷调节可以诱导电荷对称性破坏，非线性挠性电解和自由能的异常曲率依赖性。研究的pH效应超出了膜的机械弹性特性的静电重新归一化范式。
We formulate a theory of electrostatic interactions in lipid bilayer membranes where both monolayer leaflets contain dissociable moieties that are subject to charge regulation. We specifically investigate the coupling between membrane curvature and charge regulation of a lipid bilayer vesicle using both the linear Debye-Hückel (DH) and the non-linear Poisson-Boltzmann (PB) theory. We find that charge regulation of an otherwise symmetric bilayer membrane can induce charge symmetry breaking, non-linear flexoelectricity and anomalous curvature dependence of free energy. The pH effects investigated go beyond the paradigm of electrostatic renormalization of the mechano-elastic properties of membranes.
