论文标题
可调式诱导蛋白在可变形的膜管上的可激发反应扩散波
Excitable reaction-diffusion waves of curvature-inducing proteins on deformable membrane tubes
论文作者
论文摘要
活细胞利用可激发的反应扩散波来进行内部细胞功能，其中经常涉及曲率诱导蛋白。但是，其机械化学耦合的作用尚不清楚。在这里，我们报告了曲率诱导蛋白的激发反应 - 扩散波和由于变形引起的波中的交替引起的膜变形，并使用修饰的fitzhugh-nagumo模型对管状膜进行了粗晶模拟。蛋白质传播波变形管状膜，大变形引起萌芽和擦除波。波速和形状由膜变形和曲率诱导蛋白的空间分布的组合确定。波浪在方位角方向也有波动，具体取决于条件。旋转对称波局部将管子变形为对称形状，但平均保持直形形状。我们的仿真方法可以应用于其他化学反应模型，并用于研究各种生物膜现象。
Living cells employ excitable reaction-diffusion waves for internal cellular functions, in which curvature-inducing proteins are often involved. However, the role of their mechanochemical coupling is not well understood. Here, we report the membrane deformation induced by the excitable reaction-diffusion waves of curvature-inducing proteins and the alternation in the waves due to the deformation, using a coarse-grained simulation of tubular membranes with a modified FitzHugh--Nagumo model. Protein-propagating waves deform tubular membranes, and large deformations induce budding and erase waves. The wave speed and shape are determined by a combination of membrane deformation and spatial distribution of the curvature-inducing protein. Waves are also undulated in the azimuthal direction depending on the condition. Rotationally symmetric waves locally deform the tubes into a symmetric shape but maintain a straight shape on average. Our simulation method can be applied to other chemical reaction models and used to investigate various biomembrane phenomena.
