论文标题
Rabgtpase的相互关联级联的热力学不确定性关系
Thermodynamic Uncertainty Relation in the interlinked cascade of RabGTPases
论文作者
论文摘要
我们通过使用马尔可夫州的网络研究非平衡系统的通用热力学不确定性关系，对真核细胞中的RAB GTPases的众所周知的相互联系的级联进行建模。首先，我们在单个Rab物种模型和相互联系的两个Rab物种模型中都证明了TUR。我们的结果表明，当两个Rab GTPase蛋白在远离平衡时相互链接时，与单个物种交换相比，热力学成本及其精确度大大增强。这意味着，蛋白质远非平衡，试图通过在级联反应中形成互链链接来优化其生物分子过程的性能。同样，我们的结果表明，相互链接的级联反应（或振荡器）可以实现一系列可调速率常数（或频率），这表明一种维持其鲁棒性的手段。最后，我们重点介绍了热力学成本精确，三角图和疾病动力学之间的密切关系。
We model the well-known interlinked cascade of Rab GTPases found in eukaryotic cells by using a network of Markov states to investigate the universal Thermodynamic Uncertainty Relation for the non-equilibrium system. First, we prove numerically the TUR in both single Rab species model and the interlinked two Rab species model. Our results show that when two Rab GTPase proteins are interlinked at far from equilibrium, the thermodynamic cost and hence precision is greatly enhanced as compared to single species switching. This implies that at far from equilibrium, the proteins tries to optimise the precision of the performance of their biomolecular processes by forming interlinks in the cascade. Again,our results imply that the interlinked cascade (or oscillator) can achieve a range of tunable rate constants (or frequencies) which suggests a means of maintaining its robustness. Lastly, we highlight a close relation between thermodynamic cost-precision, triangular motifs and disease dynamics.
