论文标题
关于体内蓝细菌的稳健性
On the robustness of the in vivo cyanobacterial circadian clock
论文作者
论文摘要
我们提出了一个重新访问的蓝细菌昼夜节律钟的体内模型的版本。我们的目的是解决突变蓝细菌预测的鲁棒性，而无需对原始模型的转录调节。为此，我们依赖于时钟的体外模型，该模型明确描述了时钟核心蛋白的六聚体结构。如实验观察到的，我们的模型能够为突变体重现振荡行为，而无需细调的参数。
We propose a revisited version of the in vivo model of the cyanobacterial circadian clock. Our aim is to address the lack of robustness predicted for the mutant cyanobacteria without transcriptional regulation of the original model. For this, we rely on an in vitro model of the clock describing explicitly the hexameric structure of the core protein of the clock. Our model is able to reproduce oscillatory behavior for the mutant, as observed experimentally, without finely tuned parameters.
