论文标题

报告细胞类型的指南:Miracl标准

Guidelines for reporting cell types: the MIRACL standard

论文作者

Lubiana, Tiago, Roncaglia, Paola, Mungall, Christopher J., Quardokus, Ellen M., Fortriede, Joshua D., Osumi-Sutherland, David, Diehl, Alexander D.

论文摘要

细胞类型是现代生物学的根源,描述它们是人类细胞图集项目的核心任务。令人惊讶的是,没有报告新细胞类型的标准,这会导致生物医​​学文献中提到的类别和细胞本体论(细胞类型的主要注册表)之间的差距。在这里,我们介绍了有关细胞标准(Miracl)标准的最小信息报告,这是一个与科学文章一起描述细胞类型的指南。在奇迹片中,作者组织了标签,诊断描述,分类单元,解剖结构和每个感兴趣的单元格类型。 Miracl标准弥合了湿的研究人员与本体学家之间的差距,从而促进了将生物医学知识整合到本体和人工智能系统中。

Cell types are at the root of modern biology, and describing them is a core task of the Human Cell Atlas project. Surprisingly, there are no standards for reporting new cell types, leading to a gap between classes mentioned in biomedical literature and the Cell Ontology, the primary registry of cell types. Here we introduce the Minimal Information Reporting About a CelL (MIRACL) standard, a guideline for describing cell types alongside scientific articles. In a MIRACL sheet, authors organize a label, a diagnostic description, a taxon, an anatomical structure, and a parent cell class for each cell type of interest. The MIRACL standard bridges the gap between wet-lab researchers and ontologists, facilitating the integration of biomedical knowledge into ontologies and artificial intelligence systems.

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