论文标题
用于fMRI可重复性研究及其在识别异常激活图的使用的重新定义和广泛的激活量度
A Re-defined and Generalized Percent-Overlap-of-Activation Measure for Studies of fMRI Reproducibility and its Use in Identifying Outlier Activation Maps
论文作者
论文摘要
功能磁共振成像（fMRI）是研究人脑中激活的一种流行的非侵入性方式。大多数FMRI实验的最终结果是与给定范式相对应的激活图。这些地图在一项研究到另一个研究之间可能会有很大的不同，因此在几项FMRI研究中量化确定的激活的可靠性很重要。激活的重叠百分比〜\ citep {romboutsetal98，machielsenetal00}是从任何两个fMRI研究中得出的激活图之间的全局可靠性度量。 〜\ citet {jaccard1901}的相似性系数提供了一个稍微修改但更直观的度量，我们在本文中使用了它们的使用。还提出了这些措施的概括，以全面总结多个功能磁共振成像研究的可靠性。最后，开发了一种标记潜在反常研究的测试机制。该方法在涉及右手和右运动任务范式的研究中进行了说明，该范围在两个月的时间内多次由右手占主导地位的男性受试者执行，结果出色。
Functional Magnetic Resonance Imaging~(fMRI) is a popular non-invasive modality to investigate activation in the human brain. The end result of most fMRI experiments is an activation map corresponding to the given paradigm. These maps can vary greatly from one study to the next, so quantifying the reliability of identified activation over several fMRI studies is important. The percent overlap of activation~\citep{romboutsetal98,machielsenetal00} is a global reliability measure between activation maps drawn from any two fMRI studies. A slightly modified but more intuitive measure is provided by the ~\citet{jaccard1901} coefficient of similarity, whose use we study in this paper. A generalization of these measures is also proposed to comprehensively summarize the reliability of multiple fMRI studies. Finally, a testing mechanism to flag potentially anomalous studies is developed. The methodology is illustrated on studies involving left- and right-hand motor task paradigms performed by a right-hand dominant male subject several times over a period of two months, with excellent results.
