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Full-wave simulations are indispensable for nanophotonics and electromagnetics but are severely constrained on large systems, especially multi-channel ones such as disordered media, aperiodic metasurfaces, and densely packed photonic circuits where each input requires a large-scale simulation. Here we bypass the computationally demanding solution of Maxwell's equations and directly evaluate the full-wave multi-input response, with no approximation. We augment the Maxwell operator with all input source profiles and output projection profiles, followed by a single partial factorization that directly yields the entire multi-input scattering matrix via the Schur complement. This method is simple to implement and applies to any linear partial differential equation. Its advantage grows with size, being 1,000 to 30,000,000 times faster than existing methods for systems with about ten million variables. We use it to realize the first full-wave simulations of entangled-photon backscattering from disorder and all-angle characterizations of high-numerical-aperture metalenses that are thousands of wavelengths wide. This work reveals the significant efficiency gain when we rethink what to compute and enables the exploration of diverse multi-channel systems.