论文标题
全基因组关联研究的结构模型
A structural model of genome-wide association studies
论文作者
论文摘要
一种结构性遗传模型在数学上得出了对全基因组关联研究中基因组和共同实践的现代理解的结构。该模型显示了Haldane地图距离，这是基因组结构的直接结果。遗传相关的表达在模型下得出，并与BSB小鼠交叉产生的数据进行了比较。为此进行了相关测试图，并显示了模型和经验结果的密切一致性。该地块中值得注意的出发事件表明，需要进一步调查的地区。
A structural genetic model incorporating a modern understanding of the genome and common practice in genome-wide association studies is derived mathematically. The model shows the Haldane map distance as a direct consequence of the structure of the genome. An expression for genetic correlation is derived under the model and compared to data resulting from the BSB mouse cross. A correlation test plot is introduced for this comparison and shows the close agreement of the model and empirical results. Noteworthy departures in this plot indicate regions which warrant further investigation.
