论文标题
部分可观测时空混沌系统的无模型预测
Cervical Glandular Cell Detection from Whole Slide Image with Out-Of-Distribution Data
论文作者
论文摘要
宫颈腺细胞(GC)检测是计算机辅助诊断宫颈腺癌筛查的关键步骤。精确识别宫颈涂片中的GC是挑战的,其中鳞状细胞是主要的。在整个涂片线中,广泛存在的分布(OOD)数据可降低机器学习系统用于GC检测的可靠性。尽管,最新的(SOTA)深度学习模型可以胜过感兴趣的预选区域中的病理学家,但是当面对这样的吉吉像素整个幻灯片图像时,质量假阳性(FP)预测仍然无法解决。本文提出了一种基于GC的形态学知识,试图通过八个邻居中的自我发项机制来解决FP问题的形态学先验知识。它估计了GC核的极性方向。作为插件模块,Polarnet可以指导一般对象检测模型的深层特征和预测的置信度。在实验中,我们发现基于四个不同框架的通用模型可以在小图像集中拒绝FP,并将平均精度(MAP)的平均值提高到$ \ text {0.007} \ sim \ text {0.015} $平均值,最高的范围超过了最近的宫颈细胞检测模型0.037。通过堵塞Polarnet,部署的C ++程序在从外部WSI的TOP-20 GC检测准确性上提高了8.8%,同时牺牲了14.4 s的计算时间。代码可在https://github.com/chrisa142857/polarnet-gcdet中找到
Cervical glandular cell (GC) detection is a key step in computer-aided diagnosis for cervical adenocarcinomas screening. It is challenging to accurately recognize GCs in cervical smears in which squamous cells are the major. Widely existing Out-Of-Distribution (OOD) data in the entire smear leads decreasing reliability of machine learning system for GC detection. Although, the State-Of-The-Art (SOTA) deep learning model can outperform pathologists in preselected regions of interest, the mass False Positive (FP) prediction with high probability is still unsolved when facing such gigapixel whole slide image. This paper proposed a novel PolarNet based on the morphological prior knowledge of GC trying to solve the FP problem via a self-attention mechanism in eight-neighbor. It estimates the polar orientation of nucleus of GC. As a plugin module, PolarNet can guide the deep feature and predicted confidence of general object detection models. In experiments, we discovered that general models based on four different frameworks can reject FP in small image set and increase the mean of average precision (mAP) by $\text{0.007}\sim\text{0.015}$ in average, where the highest exceeds the recent cervical cell detection model 0.037. By plugging PolarNet, the deployed C++ program improved by 8.8\% on accuracy of top-20 GC detection from external WSIs, while sacrificing 14.4 s of computational time. Code is available in https://github.com/Chrisa142857/PolarNet-GCdet