论文标题
生物膜的多尺度计算建模
Multiscale Computational Modeling of Biofilm
论文作者
论文摘要
我们审查了生物膜和细菌细胞的计算模型，从考虑到这种生物学物质的无所不知的情况下，就生物膜的各种特性以及作为工程活物质（ELM）的潜在的观点提供了观点。 MinireView从分子状态开始，从小到中尺度开始，直到连续体，重点是中尺度算法，例如耗散颗粒动力学（DPD）和基于个体的建模（IBM）。考虑到每个量表上的不同建模方法，突出显示了一些代表性的作品。鉴于存在的研究工作，详细阐述了每种算法的优势和局限性。具体而言，IBM的潜力（也称为离散元素方法（DEM））是针对其对生物学和机械性能的准确描述的目标。
We review the computation models for biofilm and bacteria cells, providing perspectives on biofilm's various properties and potential serving as engineering living materials (ELMs), considering the omnipresence of such biological matter. The minireview starts from the molecular regime, bottom-up to the mesoscale, to continuum, with an emphasis on the mesoscale algorithms such as dissipative particles dynamics (DPD) and individual-based modeling (IbM). Some representative works are highlighted considering different modeling methods on each scale. The advantages and limitations of each algorithm for different scales are elaborated given the existed research works. Specifically, the potential for IbM, also known as the discrete element method (DEM) is targeted for its accurate description of both biological and mechanical properties.
