论文标题
铅笔光束扫描闪光质子疗法的最新进展:叙事评论
Recent Progress in Pencil Beam Scanning FLASH Proton Therapy: A Narrative Review
论文作者
论文摘要
背景和目标:与常规剂量率RT相比,使用超高剂量辐射疗法(FLASH-RT)的最新实验研究表明,已改善了正常组织的保留和可比的肿瘤控制。具有优质剂量法特征的铅笔梁扫描(PBS)质子疗法已开始引起人们对临床前研究的共形闪存-RT的关注。这篇评论旨在提供有关PBS Flash-RT开发的最新更新。方法:本评论文章中总结的信息基于PubMed和Google Scholar等数据库中的搜索结果,其中包括铅笔梁扫描,质子治疗,质子闪光灯,Bragg Peak Flash等,包括2014-2022年的英文文章。内容和发现:本综述总结了PBS Flash质子治疗(Flash-PT)的最新发展,包括PBS剂量率表征,当前的递送限制,治疗计划和生物学研究。结论:随着PBS Flash传递能够使用传输梁成功进行生物学研究,PBS Bragg Peak Flash Technologies的进一步改进将导致更高级的治疗计划与潜在改善的结果相关。
Background and Objective: Recent experimental studies using ultra-high dose rate radiation therapy (FLASH-RT) have shown improved normal tissue sparing and comparable tumor control compared to conventional dose rate RT. Pencil beam scanning (PBS) proton therapy with superior dosimetry characteristics has begun to draw attention to the delivery of conformal FLASH-RT for preclinical studies. This review aims to provide recent updates on the development of PBS FLASH-RT. Methods: The information summarized in this review article is based on search results in databases such as PubMed and search engines like Google Scholar, with keywords including pencil beam scanning, proton therapy, proton FLASH, Bragg peak FLASH, etc., with English articles from the year of 2014-2022. Content and Findings: This review summarizes of recent developments in PBS FLASH proton therapy (FLASH-PT), including PBS dose rate characterization, current delivery limitations, treatment planning, and biological investigations. Conclusions: As PBS FLASH delivery has enabled successful biological studies using transmission beams, the further improvement in PBS Bragg peak FLASH technologies will result in more advanced treatment plans associated with potentially improved outcomes.