论文标题
非接触式声学微调光学相干弹性图，用于评估紫外线/核黄素胶原蛋白交叉链接后角膜的生物力学变化：EX VIVO人类研究
Non-contact acoustic micro-tapping optical coherence elastography for evaluating biomechanical changes in the cornea following UV/riboflavin collagen cross linking: ex vivo human study
论文作者
论文摘要
目的：评估使用非接触式声学微调光学相干性弹性弹性（Aut-OCE）设计的外体角膜各向异性弹性特性的变化：使用正常和cxl的供体供体性cornory cornity cornity cornity cornory cornity cornory cornity cornory cornory cornory cortos cornory cornity cornory cortos cornory corn cort cort量：微敲击光学连贯性弹性弹力图（Aut-OCE）主要结局指标：角膜弹性模量（面内Young的E，E和平面外剪切，G）可以在正常和CXL处理的组织中以及使用非接触式Aut-Ouce进行CXL手术过程中评估。结果：CXL引起人角膜的拉伸和剪切模量的显着增加。面板内模量E = 3U的配对研究（前后，n = 7）的平均值从19 MPa增加到43 MPa，而平面外剪切模量G，G，GPA的平均值从188 kPa增加到673 kpa。亚组中的机械测试支持CXL诱导的角膜模量发生变化，并且通常与自动相一致。结论：人角膜是一种高度各向异性的材料，其平面机械性能与平面外的材料大不相同。非接触式汽车可以测量因UV-CXL而导致人角膜各向异性弹性特性的变化。
Purpose: To evaluate changes in the anisotropic elastic properties of ex vivo human cornea treated with UV cross-linking (CXL) using non-contact acoustic micro-tapping Optical Coherence Elastography (AuT-OCE) Design: AuT performed on normal and CXL ex vivo human donor cornea Methods: Elastic properties of normal and UV CXL treated human corneas were quantified using non-contact acoustic micro-tapping Optical Coherence Elastography (AuT-OCE) Main Outcome Measures: Corneal elastic moduli (in-plane Young's, E, and out-of-plane shear, G) can be evaluated in both normal and CXL treated tissues, as well as during the CXL procedure using non-contact AuT-OCE. Results: CXL induced a significant increase in both the tensile and shear moduli in human cornea. The mean in the paired study (pre- and post-, n=7) of the in-plane Young's modulus, E=3u, increased from 19 MPa to 43 MPa while the out-of-plane shear modulus, G, increased from 188 kPa to 673 kPa. Mechanical tests in a subgroup support CXL-induced cornea moduli changes and generally agree with AuT-OCE. Conclusions: The human cornea is a highly anisotropic material where in-plane mechanical properties are very different from those out-of-plane. Non-contact AuT-OCE can measure changes in the anisotropic elastic properties in human cornea as a result of UV-CXL.
