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The use of Digital Twins is set to transform the manufacturing sector by aiding monitoring and real-time decision making. For several applications in this sector, the system to be modeled consists of a mix of discrete-event and continuous processes interacting with each other. Building simulation-based Digital Twins of such systems necessitates an open, flexible simulation framework which can support easy modeling and fast simulation of both continuous and discrete-event components, and their interactions. In this paper, we present an outline and key design aspects of a Python-based framework for performing mixed discrete-continuous simulations. The continuous processes in the system are assumed to be loosely coupled to other components via pre-defined events. For example, a continuous state variable crossing a threshold may trigger an external event. Similarly, external events may lead to a sudden change in the trajectory, state value or boundary conditions in a continuous process. We first present a systematic events-based interface using which such interactions can be modeled and simulated. We then discuss implementation details of the framework along with a detailed example. In our implementation, the advancement of time is controlled and performed using the event-stepped engine of SimPy (a popular discrete-event simulation library in Python). The continuous processes are modelled using existing frameworks with a Python wrapper providing the events interface. We discuss possible improvements to the time advancement scheme, a roadmap and use cases for the framework.