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We introduce a generalized additive model for location, scale, and shape (GAMLSS) next of kin aiming at distribution-free and parsimonious regression modelling for arbitrary outcomes. We replace the strict parametric distribution formulating such a model by a transformation function, which in turn is estimated from data. Doing so not only makes the model distribution-free but also allows to limit the number of linear or smooth model terms to a pair of location-scale predictor functions. We derive the likelihood for continuous, discrete, and randomly censored observations, along with corresponding score functions. A plethora of existing algorithms is leveraged for model estimation, including constrained maximum-likelihood, the original GAMLSS algorithm, and transformation trees. Parameter interpretability in the resulting models is closely connected to model selection. We propose the application of a novel best subset selection procedure to achieve especially simple ways of interpretation. All techniques are motivated and illustrated by a collection of applications from different domains, including crossing and partial proportional hazards, complex count regression, non-linear ordinal regression, and growth curves. All analyses are reproducible with the help of the "tram" add-on package to the R system for statistical computing and graphics.