论文标题
预测对不同环境条件的自适应演变的交叉态度：表型降低的结果
Prediction of Cross-Fitness for Adaptive Evolution to Different Environmental Conditions: Consequence of Phenotypic Dimensional Reduction
论文作者
论文摘要
对一种环境压力的适应性进化如何改善或抑制对另一种环境的适应是进化生物学的一个重要问题。例如，在微生物学中，细菌对不同抗生素具有抗性的进化是一个关键问题，已被研究为跨耐药性。实际上，关于细菌的最新实验表明，它们向各种压力环境的进化可以通过在施加压力时的转录组变化来预测。但是，到目前为止尚无研究来解释交叉抗性与转录组变化之间可能存在的理论关系，这会导致细胞表型的高维变化。在这里，我们表明，使用具有高维表型的细胞模型，应力耐受性演变的适应性变化与对环境的反应之间存在相关性，并理论上建立了关系。目前的结果允许在进化前对不同应力的转录组信息进行进化。讨论了这与微生物进化实验的相关性。
How adaptive evolution to one environmental stress improves or suppresses adaptation to another is an important problem in evolutionary biology. For instance, in microbiology, the evolution of bacteria to be resistant to different antibiotics is a critical issue that has been investigated as cross-resistance. In fact, recent experiments on bacteria have suggested that the cross-resistance of their evolution to various stressful environments can be predicted by the changes to their transcriptome upon application of stress. However, there are no studies so far that explain a possible theoretical relationship between cross-resistance and changes in the transcriptome, which causes high-dimensional changes to cell phenotype. Here, we show that a correlation exists between fitness change in stress tolerance evolution and response to the environment, using a cellular model with a high-dimensional phenotype and establishing the relationship theoretically. The present results allow for the prediction of evolution from transcriptome information in response to different stresses before evolution. The relevance of this to microbiological evolution experiments is discussed.
