论文标题

拉动,推或失败:基因驱动的人口影响会改变其空间传播的性质

Pulled, pushed or failed: the demographic impact of a gene drive can change the nature of its spatial spread

论文作者

Kläy, Léna, Girardin, Léo, Calvez, Vincent, Débarre, Florence

论文摘要

在任何现场实验之前,了解基因驱动等位基因的时间扩散 - 通过建模偏向其自身传播的等位基因。在本文中,我们提出了一个确定性反应扩散模型,该模型描述了在一维空间上下文中人口统计学和等位基因动力学之间的相互作用。我们专注于行驶波解决方案,更具体地说,是基因驱动入侵的速度(如果成功的话)。我们考虑了基因转化的各种时间(在合子中或种系中)和基因转化的不同概率(而不是假设先前工作中所做的100 $ \%$ cenversion)。当人口的内在增长率达到极端值时,我们比较了传播的类型,无论是非常大还是很低。当它是无限大的时候,波浪可以成功或不成功,如果成功,可以将其拉出或推动,与以前的研究一致(此处扩展到部分转换的情况)。相反,当内在增长率消失时,它不能推动。在这种情况下,通过与流行病学SI模型的有见地的联系获得了分析结果。我们进行了广泛的数值模拟,以弥合大小生长速率的两个机制之间的差距。我们猜想,如果将其拉到两个极端机制中,则始终将波浪拉动,并且波速与生长速度无关。例如,当健身成本足够小时,或者在成功驱动入侵后人口的驱动器和野生型共存时,发生这种情况。我们的模型有助于描绘人口动态影响基因驱动的传播的条件。

Understanding the temporal spread of gene drive alleles -- alleles that bias their own transmission -- through modeling is essential before any field experiments. In this paper, we present a deterministic reaction-diffusion model describing the interplay between demographic and allelic dynamics, in a one-dimensional spatial context. We focused on the traveling wave solutions, and more specifically, on the speed of gene drive invasion (if successful). We considered various timings of gene conversion (in the zygote or in the germline) and different probabilities of gene conversion (instead of assuming 100$\%$ conversion as done in a previous work). We compared the types of propagation when the intrinsic growth rate of the population takes extreme values, either very large or very low. When it is infinitely large, the wave can be either successful or not, and, if successful, it can be either pulled or pushed, in agreement with previous studies (extended here to the case of partial conversion). In contrast, it cannot be pushed when the intrinsic growth rate is vanishing. In this case, analytical results are obtained through an insightful connection with an epidemiological SI model. We conducted extensive numerical simulations to bridge the gap between the two regimes of large and low growth rate. We conjecture that, if it is pulled in the two extreme regimes, then the wave is always pulled, and the wave speed is independent of the growth rate. This occurs for instance when the fitness cost is small enough, or when there is stable coexistence of the drive and the wild-type in the population after successful drive invasion. Our model helps delineate the conditions under which demographic dynamics can affect the spread of a gene drive.

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