论文标题
接受分化甲状腺癌的碘131治疗的患者的紧密接触限制期
Close contact restriction periods for patients who received iodine-131 therapy for differentiated thyroid cancer
论文作者
论文摘要
客观的。接受放射性核素治疗治疗的患者可能需要在治疗后一段时间内对某些活动进行限制，以优化公众的保护，并确保不超过法定剂量限制。软件可用于根据放射性药物给药的纵向剂量率测量值来计算个体的必要限制周期。在过去的二十年中，在澳大利亚医院中已使用电子表格计划用于此目的。但是，该电子表格有一个限制，因为它在接触模式的剂量计算中使用了近似，这会影响计算的限制周期。开发了一个名为DORN的计算机程序，该程序提供了与电子表格相同的功能，但没有此近似值。比较了Dorn和电子表格的辐射安全建议。方法。比较了55例接受分化甲状腺癌的碘131治疗的患者的电子表格和DORN的建议。主要结果。照顾婴儿的限制期，与儿童的密切接触以及与伴侣睡觉的时间通常比电子表格长约13个小时，但在某些情况下，较短或一个月的时间更短或一个月。意义。如果在临床上使用DORN计划代替电子表格，则某些患者将享受较短的限制期，并且治疗提供者可以对他们遵守监管要求和最佳实践更有信心。 Dorn可以从https://doi.org/jg5f免费获得。
Objective. Patients treated with radionuclide therapy may require restrictions on certain activities for a period of time following treatment to optimise protection of the public and ensure the legal dose limit is not exceeded. Software may be used to calculate necessary restriction periods for an individual based on longitudinal dose rate measurements from the time of radiopharmaceutical administration. A spreadsheet program has been used for this purpose in Australian hospitals for the last two decades. However, this spreadsheet has a limitation in that it uses an approximation in the calculation of dose from a contact pattern, which affects the calculated restriction period. A computer program called Dorn was developed that provides the same functionality as the spreadsheet but without this approximation. Proffered radiation safety advice from Dorn and the spreadsheet were compared. Approach. Advice from the spreadsheet and Dorn were compared for 55 patients who underwent iodine-131 therapy for differentiated thyroid cancer. Main results. The restriction periods for caring for infants, close contact with children and sleeping with a partner were typically about 13 hours longer in Dorn than in the spreadsheet, but in some cases were over a week shorter or a month longer. Significance. If the Dorn program is used clinically in place of the spreadsheet, some patients will enjoy shorter restriction periods and the therapy provider can be more confident in their compliance with regulatory requirements and best practice. Dorn is freely available from https://doi.org/jg5f.
